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Health vs Hype with the American Medical Association

Health vs Hype with the American Medical Association

HRT and Menopause: What Does the Science Actually Say?

Oct 13, 2026 · 30m

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About this episode

Hormone replacement therapy (HRT) is everywhere right now, but what does the science actually say about HRT for menopause and perimenopause? In this episode of Health vs. Hype , Trace Dominguez separates the evidence from the hype around one of the most debated topics in women’s health. Dr. Elizabeth Lapeyre, a board-certified OB-GYN and menopause specialist, explains what happens to estrogen and progesterone during perimenopause and menopause, which symptoms hormone therapy can help, and how the risks and benefits of HRT have changed as the science has evolved. We look at the history of the Women’s Health Initiative study, why its findings had such a lasting impact on how…