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Laugh Lines with Kim & Penn Holderness

Laugh Lines with Kim & Penn Holderness

Kicking Alzheimer's Butt & Your Questions with Dr. Richard Isaacson

May 5, 2026 · 57m

Coming soon to iPhone. Already have it? “Listen in Starcast” takes you straight there.

On this episode

About this episode

If you’ve been following along, you know Penn recently found out he has two copies of the APOE4 gene - basically the “high risk” genetic lottery for Alzheimer’s. And while we thought we were prepared for that news… we weren’t. It hit hard. For both of us. But this episode is not about fear. It’s about hope. This week we are sitting down (again!) with Dr. Richard Isaacson (the brain behind Penn’s prevention plan and one of the leading voices in Alzheimer’s prevention) to answer YOUR questions. And wow, did you have questions. We discuss what to actually ask your doctor, what Penn is doing right now, prevention strategies that are showing promise, and how close we are to affordable, at-home…