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The Rest Is Science

The Rest Is Science

Something Weird Is Going On With Placebos

Oct 11, 2026 · 50m

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About this episode

For the past few decades, something strange has been happening in clinical trials. Painkillers aren't getting worse, but the placebos they're tested against appear to be getting better. In one landmark study, the advantage of pain medication over placebo shrank from 27.3% in 1996 to just 8.9% in 2013. Even stranger? This trend was found almost entirely in American trials.In this episode of The Rest Is Science, Professor Hannah Fry and Michael Stevens (Vsauce) investigate the extraordinary science of the placebo effect; how our expectations influence pain, why belief can change the way our bodies respond, and what this means for the future of medicine. Why does the way a treatment is…