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The Proof with Simon Hill

The Proof with Simon Hill

Lowering cholesterol with medicine | Dr Thomas Dayspring and Dr Dan Soffer

Sep 1, 2025 · 1h 50m

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On this episode

About this episode

In this episode, I’m joined by Dr Tom Dayspring and Dr Dan Soffer for a comprehensive look at lipid-lowering therapy. We unpack the science behind statins, ezetimibe, PCSK9 inhibitors, fibrates, and newer agents like bempedoic acid, asking what really works, who should take them, and how early treatment might prevent disease. From guideline thresholds to real-world decision making, historical trials to future therapies, this conversation offers clarity on one of the most important areas in cardiovascular prevention. In this episode, we cover: What lipid-lowering therapy actually is Statins, ezetimibe, fibrates, and PCSK9 inhibitors How these drugs work and who benefits most Absolute vs…