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The Dan Buettner Podcast

The Dan Buettner Podcast

The VO2 Max Threshold: The Exact Exercise Intensity That Rewinds Your DNA Clock

Oct 1, 2026 · 1h 31m

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About this episode

Why does 10,000 steps a day barely budge your biological clock, while a high-intensity workout can actively turn back the clock on your DNA? Pioneering geneticist Dr. Steve Horvath joins Dan Buettner to expose what really drives epigenetic aging—and why expensive biohacking shortcuts often fall flat. Discover the exact VO2 max threshold required to reverse your cellular age, the truth behind popular longevity drugs like rapamycin, and simple, low-cost daily habits that protect your muscle mass and lower multi-morbidity risk. Stop guessing with your health and learn the proven, science-backed mechanisms to keep your mind and body young. Learn more about your ad choices. Visit…