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The a16z Show

The a16z Show

Why Real-World AI Is Harder Than the Benchmark | EliseAI’s Mario Martone

Oct 18, 2026 · 24m

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What changes when an AI mistake doesn’t just hurt a benchmark score, but affects someone’s housing or healthcare? EliseAI Head of Applied Research Mario Martone argues that deploying AI in essential industries requires a very different standard of reliability. Mario joins MTS to explain how EliseAI handles roughly 5 million phone calls a month, why LLMs aren’t the right solution for every problem, and how the team combines language models, traditional machine learning, neural networks, and internally built evaluations to decide what actually works in production. Drawing on 15 years studying theoretical physics, Mario also explains how the scientific method shapes EliseAI’s research culture,…