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unPAUSED with Dr. Mary Claire Haver

unPAUSED with Dr. Mary Claire Haver

Mast Cells, Histamine, and Perimenopause Explained: MCAS, Anxiety, Estrogen

May 9, 2026 · 45m

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About this episode

In this bonus episode of unPAUSED, Dr. Mary Claire Haver is joined by Dr. Zachary Rubin, double board certified allergist and immunologist and New York Times bestselling author of All About Allergies, to dig into the connection between histamine, mast cells, and women's hormonal health. Dr. Rubin breaks down what mast cells are, how histamine works across multiple organ systems, and why women are disproportionately affected by mast cell related conditions including mast cell activation syndrome (MCAS). The two dig into the estrogen and histamine connection, why perimenopause can trigger or worsen symptoms like anxiety, brain fog, and histamine intolerance, and what MCAS actually is and how…