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Your Brain on Hormones: What Every Woman Should Know About Mood & Mental Health

Jun 29, 2026 · 56m

Coming soon to iPhone. Already have it? “Listen in Starcast” takes you straight there.

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About this episode

Ever feel like you become a completely different person the week before your period? Maybe you're suddenly overwhelmed with anxiety, rage, irritability, insomnia, or intrusive thoughts, and then your period arrives and it's like a switch flips. If you've ever wondered whether it's "just PMS" or something more, you're not alone. In this episode, Dr. Lucky Sekhon and Dr. Alicia Robbins sit down with reproductive psychiatrist Dr. Sarah Oreck to unpack the complex relationship between hormones and mental health. Together, they discuss between PMS and PMDD, and the role of estrogen, progesterone, serotonin, dopamine, and GABA in mood regulation. The conversation also dives into PMDD treatment…