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Extend Podcast with Darshan Shah, MD

Extend Podcast with Darshan Shah, MD

152. Nick Norwitz: Cholesterol Myths, Insulin Resistance, and the Real Drivers of Heart Disease

Apr 2, 2026 · 1h 18m

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About this episode

Cholesterol remains one of the most debated biomarkers in cardiovascular medicine, yet many people still misunderstand what it actually tells us about metabolic health and disease risk. As research evolves, the conversation is shifting from simple cholesterol numbers toward deeper drivers of cardiometabolic dysfunction. In this episode of Extend, we sit down with Nick Norwitz, metabolic health researcher and physician scientist, to unpack the science behind cholesterol, insulin resistance, and cardiovascular risk. We break down the difference between LDL and ApoB, why insulin resistance may be a stronger predictor of heart disease, how statins work beyond cholesterol lowering, and what…