LDL on Keto: What Happens When Ezetimibe Enters the Picture? | Dr. Josh Wageman, Dr. Laura Buchanan, and Dr. Matt Calkins - E460

About this episode

A ketogenic diet can dramatically improve metabolic health while sending LDL-C through the roof. So what's actually happening? Dr. Josh Wageman and Dr. Laura Buchanan break down their new study, "Increased LDL-C reduction with ezetimibe in ketogenic diet-induced hypercholesterolemia." The results raise some fascinating questions. In 14 patients who developed very high LDL-C while following a ketogenic diet, ezetimibe cut median LDL-C from 254 to 127 mg/dL—a remarkable 53% reduction. Why was the response so much greater than what's typically seen with ezetimibe? Could altered cholesterol absorption help explain why some people experience dramatic LDL increases on keto? Josh Wageman, Matt…