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NEJM AI Grand Rounds

NEJM AI Grand Rounds

Medicine, Machines, and Magic: Dr. Jonathan Chen on Medical AI

Oct 15, 2025 · 48m

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On this episode

About this episode

In this episode, Dr. Jonathan Chen joins the hosts to discuss his path from teenage programmer to Stanford physician-informatician and why machine learning has both thrilled and unnerved him. From his 2017 NEJM essay warning about “inflated expectations” to his latest studies showing GPT‑4 outperforming doctors on diagnostic tasks, Dr. Chen describes a discipline learning humility at machine speed. This conversation spans medical education, automation anxiety, magic, and why empathy—not memorization—may become the most valuable clinical skill. Transcript.