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Longevity Optimization with Kayla Barnes-Lentz

Longevity Optimization with Kayla Barnes-Lentz

Dr. Colleen Cutcliffe, PhD: Natural GLP-1 Production, Fiber Deficiency, Akkermansia and the Gut Microbiome Connection

Jul 31, 2026 · 1h 18m

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About this episode

Most people think of the gut as a digestive organ. It is not. It is the upstream controller of your metabolism, immune function, brain health, skin, and hormones and almost everyone is running it on a depleted, misfed microbiome without knowing it. Dr. Colleen Cutcliffe, PhD is the co-founder and CEO of Pendulum Therapeutics, holds a PhD in biochemistry from Johns Hopkins, and spent over 15 years in pharma and biotech before pioneering next-generation probiotic science. Her team was the first in the world to manufacture Akkermansia, a strain found at high levels in virtually every centenarian population studied and depleted in almost every major chronic disease. What makes this conversation…