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Dwarkesh Podcast

Dwarkesh Podcast

Reiner Pope – Chip design from the bottom up

May 22, 2026 · 1h 21m

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About this episode

New blackboard lecture with Reiner Pope: how do chips actually work - starting with basic logic gates, and working up to why GPUs, TPUs, FPGAs, and the human brain each look the way they do. Reiner is CEO of MatX , a new chip startup (full disclosure - I’m an angel investor). He was previously at Google, where he worked on software efficiency , compilers, and TPU architecture. Watch this one on YouTube so you can see the chalkboard. Read the transcript . Sponsors * Crusoe was one of only five GPU clouds that made the gold tier in SemiAnalysis' most recent ClusterMAX report. Gold-tier providers like Crusoe delivered 5-15% lower TCO than silver-tier clouds, even with identical GPU pricing.…