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American History Hotline

American History Hotline

Why Did Disease Devastate Native Americans—but Not European Colonists? | Charles C. Mann

Aug 5, 2026 · 33m

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About this episode

Guns, germs and steel. Emphasis on GERMS. When Europeans arrived in the Americas, they brought all sorts of diseases! A listener asks: Why did diseases like smallpox devastate Native American populations but not European colonists? Was it simply a lack of immunity, or is the story more complicated? To get answers, Bob calls up bestselling author and journalist Charles C. Mann, author of 1491 and 1493 , to explore one of the most consequential—and misunderstood—chapters in American history. Together they discuss: • What North America looked like before Columbus • Why Native societies were far larger and more sophisticated than many people realize • How diseases such as smallpox, malaria, and…